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Diabetes modré světlo


MODY 3 is a form of maturity onset diabetes of the young. MODY 3 (also known as HNF1A-MODY) is caused by mutations of the HNF1-alpha gene, a homeobox gene on chromosome 12. This is the most common type of MODY in populations with European ancestry, accounting for about 70% of all cases in Europe.



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MODY is the name given to a collection of different types of inherited forms of diabetes that usually develop in adolescence or early adulthood. MODY stands for “Maturity-onset diabetes of the young” and was given that name because it acted like an adult type of diabetes but was found in young people.

Some more links:
-> Mezinárodní léky na diabetes
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Most mutations that cause monogenic diabetes reduce the body’s ability to produce insulin, a protein produced in the pancreas that helps the body use glucose for energy. Neonatal diabetes mellitus (NDM) and maturity-onset diabetes of the young (MODY) are the two main forms of monogenic diabetes. NDM occurs in newborns and young infants.
-> Patogeneze diabetes mellitus závislá na inzulínu
Maturity Onset Diabetes of the Young (MODY) is an inherited form of diabetes mellitus. It is caused by a change in one of eleven genes. Up to 5% of all diabetes cases may be due to MODY. Just like other people with diabetes, people with MODY have trouble regulating their blood sugar levels.
-> Vylučování velkého množství diabetu moči
MODY 5 often result in diabetes in combination with a structural kidney or kidney tract problem. Mutations can occur spontaneously but usually are passed on from a parent to a child. If a parent has MODY 5 there is a 50% chance that a child will inherit the mutation and be at risk of developing diabetes at a young.
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